How is it that your body with all of its specialized organs developed from a single cell? Scientists are exploring how gene expression patterns and their timing regulate cell differentiation. Today, ...

A research team has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation from stem ...

Single cell gene expression studies often rely on single-cell RNA sequencing (scRNA-seq) alone. While scRNA-seq reveals which genes are turned on, it does not capture protein expression or changes to ...

A newly identified cellular system monitors subtle variations in genetic coding, hinting at a hidden level of control over ...

For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the ...

Researchers identified DHX29 as a key protein that detects non-optimal codons and represses inefficient mRNAs, revealing how ...

DNA can also be demethylated, either through passive or active processes. Passive DNA demethylation occurs when the methylation pattern is not replenished during DNA replication and gradually ...

Researchers at Harvard’s Wyss Institute and Tufts University have engineered frog-cell constructs that autonomously assemble ...

Scientists usually study the molecular machinery that controls gene expression from the perspective of a linear, ...

Cancers emerge from many different paths. One path begins early, in embryonic development, when a protein complex called PRC2 ...